top of page
  • Facebook
  • Twitter
  • Instagram
DNA background

POPULATION-AWARE POLYGENIC RISK ASSESSMENT

From Genetic Diversity to
Predictive Clarity

V-RISK translates polygenic information into clear cardiovascular and metabolic risk insights. Designed for integration into professional healthcare pathways, it supports more informed risk assessment, prevention planning and patient communication.

Developed for laboratories, clinicians and healthcare partners.

V-RISK

01 / V-RISK

A More Complete View of Inherited Risk

Conventional risk assessment focuses primarily on clinical and lifestyle factors. Yet a substantial component of susceptibility to common diseases is distributed across thousands of genetic variants and may remain undetected by conventional genetic testing.

 

V-RISK uses polygenic risk scores to estimate this cumulative inherited susceptibility. Results are interpreted in population context and presented through structured reports designed to support—not replace—clinical evaluation and established risk assessment tools.

image2.png
Why V-Risk

02 / WHY V-RISK

Genetic Risk Made More
Relevant and Actionable

01. Population-Aware Interpretation

Genetic background can influence the performance and interpretation of polygenic risk scores. V-RISK incorporates population context to support more appropriate and transparent risk assessment across diverse individuals.

03. Integrated Risk Context

Genetic susceptibility is considered alongside relevant clinical and lifestyle factors, supporting a broader view of individual risk.

02. Clinically Relevant Reporting

Complex genomic results are translated into structured risk categories, concise explanations and practical points for clinical discussion.

04. Professional Delivery

V-RISK is designed for use through laboratories, clinicians and healthcare organizations rather than as a direct-to-consumer genetic test.

Panel-Coverage

03 / PANEL COVERAGE

Genetic Risk Made More
Relevant and Actionable

V-RISK assesses inherited susceptibility across selected cardiovascular, metabolic and lipid-related phenotype

CARDIOVASCULAR RISK

01—03

METABOLIC AND LIPID RISK

04—08

04 / HOW IT WORKS

From Sample to

Structured Risk Insight

01—03

01

02

03

04

Sample and

Genotyping

A DNA sample is processed using an established SNP genotyping workflow through an authorized laboratory.

Quality Control and Population Context

Genotype data undergo defined quality-control procedures and population-aware analytical assessment.

Polygenic

Risk Analysis

Validated computational workflows calculate risk scores for the phenotypes included in the panel.

Structured Reporting

Results are presented using clear risk categories, supporting explanations and audience-appropriate recommendations for professional review and communication.

05 / REPORTING

Designed for Clearer
Clinical Communication

Polygenic risk is probabilistic rather than deterministic. V-RISK reports are therefore designed to communicate both the potential relevance and the limitations of each result.

A polygenic risk result does not diagnose disease. It provides an additional layer of information that should be interpreted together with clinical findings, family history and established risk factors.

01

Clear risk stratification and Population-aware interpretation

02

Disease-specific result summaries and Individual-facing explanations

03

Clinician-facing interpretation points and elevant clinical and lifestyle context

04

Transparent limitations and multilingual reporting options

CONTACT US

Reach out to us using the form below:

Variome B.V. | John M. Keynesplein 1, 1066 EP Amsterdam, The

Netherlands

SUBSCRIBE TO OUR NEWSLETTER

© 2026 by Variome. Innovating Genomics.

bottom of page